Enzymes used in the synthesis of DPM.

aAbbreviations: ACS, acetyl-CoA synthetase; ACT, acetoacetyl-CoA thiolase; HMGS2, HMG-CoA synthase; ThRed, acetoacetyl-CoA thiolase/HMG-CoA reductase (dual-function enzyme); HMGR, HMG-CoA reductase; MVK, mevalonate kinase; PMK, phosphomevalonate kinase; PK, pyruvate kinase; MK, myokinase; PPiase, inorganic pyrophosphatase.bObtained from commercial sources.cExpressed in E. coli and purified.dStandard errors are Materials and Methods).eParameters taken from literature (MK [77], [78], PPiase [79], [80]).