Multi-Omics Characterization of Developing Forebrain Organoids Unravels the Dynamic Molecular Events of Rett Syndrome Pathogenesis [RNA-seq data]

To elucidate the molecular events contributing to Rett Syndrome pathogenesis, we analysed the multi-omics profile of MeCP2-mutant (RTT) and isogenic control (IC) forebrain organoids. Dorsal and ventral forebrain organoids were cultured for 75 days. Transcriptomics and proteomics profiles were characterized at days 0, 13, 40, and 75, corresponding to distinct neurodevelopmental phases. This record includes the RNA-seq and corresponding meta data files.