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Synthesis and Reactivity of 1,2-Dioxolanes from β,γ-Epoxy Ketones

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https://figshare.com/articles/dataset/Synthesis_and_Reactivity_of_1_2_Dioxolanes_from_Epoxy_Ketones/2292037
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Five-membered ring peroxides were prepared in one step in 31–86% yield from readily accessible β,γ-epoxy ketones and H2O2. The reaction proceeded via a tetrahydrofuran, which was converted to the thermodynamically favored 1,2-dioxolane. The product contains a leaving group, which can be displaced to synthesize analogues of the plakinic acid natural products.
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2014-05-16
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