MYC

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

该基因是一种原癌基因，编码一种参与细胞周期进展、细胞凋亡和细胞转化的核磷蛋白。编码的蛋白与相关的转录因子MAX形成异源二聚体。该复合物与E框DNA同源序列结合，调控特定靶基因的转录。该基因的扩增在多种人类癌症中频繁观察到。涉及该基因的易位与人类患者中的Burkitt淋巴瘤和多发骨髓瘤相关。有证据表明，翻译起始既可从上游的编码非AUG（CUG）位点，也可从下游的AUG起始位点，从而产生具有不同N端的两类异构体。[由RefSeq提供，2017年8月]