Toward a Better Understanding of Potential Roles of Astrocytes in HIV-1-associated Neurocognitive Disorders

ChEBI2009-08-05 更新2026-07-21 收录

HIV神经认知障碍机制

胶质细胞功能研究

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-17383 数据链接链接失效反馈

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Toward a Better Understanding of Potential Roles of Astrocytes in HIV-1-associated Neurocognitive Disorders

创建时间：

2009-08-05

The RNA sequencing of brain after microglial depletion and repopulation. The RNA sequencing of brain after microglial depletion and repopulation

胶质细胞功能研究

神经免疫转录组学

The RNA sequencing of brain after microglial depletion and repopulation Overall design: Brain mRNA profiles of adult wild type C57BL/6J mice, after treatments of PLX5622, control diet (CD), LPS, vehic

NIAID Data Ecosystem130

Transplantation of wild-type hematopoietic stem and progenitor cells rescue Alzheimer’s disease in a mouse model and highlights the central role of microglia in disease pathogenesis. Transplantation of wild-type hematopoietic stem and progenitor cells rescue Alzheimer’s disease in a mouse model and highlights the central role of microglia in disease pathogenesis

阿尔茨海默病细胞治疗

胶质细胞功能研究

Alzheimer’s disease (AD) is the most prevalent cause of dementia, but still no effective treatment exists. Microglia have been implicated in AD pathogenesis, but their role is still matter of debate.

NIAID Data Ecosystem70

An investigation into the effects of ATV:Trem2 on AD model mice using scRNA-seq

阿尔茨海默病转录组

胶质细胞功能研究

WT hTfR-KI mice and APP/SAA hTfR-KI mice were treated with one of: Isotype control ATV, naked 4D9 (activating Trem2 Ab), or ATV:4D9. Drugs were delivered IV. After 24 hours, mice were sacrificed, and

NIAID Data Ecosystem40

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation [Hs]

阿尔茨海默病分子机制

胶质细胞功能研究

We identified enrichment of a disease-enhancing, proinflammatory subpopulation of microglia in human AD patient brains with the R47H-TREM2 mutation, and uncovered that enhanced Akt signaling in microg

NIAID Data Ecosystem80

Generation of human microglia-like cells to study neurological disease. Homo sapiens

神经退行性疾病模型

胶质细胞功能研究

Microglia play important roles in developmental and homeostatic brain function, and influence the establishment and progression of many neurological disorders. Here, we demonstrate that renewable huma

NIAID Data Ecosystem50

Toward a Better Understanding of Potential Roles of Astrocytes in HIV-1-associated Neurocognitive Disorders

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