Enantioselective Conjugate Additions of α‑Amino Radicals via Cooperative Photoredox and Lewis Acid Catalysis

We
report the highly enantioselective addition of photogenerated
α-amino radicals to Michael acceptors. This method features
a dual-catalyst protocol that combines transition metal photoredox
catalysis with chiral Lewis acid catalysis. The combination of these
two powerful modes of catalysis provides an effective, general strategy
to generate and control the reactivity of photogenerated reactive
intermediates.