DCC interaction with Netrin-1

Netrin-1 promotes attraction of the commissural neurons to midline cells. It is secreted in the ventral midline (also known as the floor plate). The transmembrane DCC receptor is a Netrin-1 receptor, involved in the attractive effects of Netrin-1. Contact-dependent mechanisms promote extension of growth cones across the floor plate to the contralateral side, whereupon growth cones acquire sensitivity to the midline repellent Slit and grow away from the midline.<br>Netrin-1 binds directly to the fifth Fibronectin III motif of DCC, thereby inducing DCC clustering through the association between the DCC P3 domains, a process required for an attractive response.

Netrin-1促进 commissural 神经元对中线细胞的吸引。该物质分泌于腹侧中线区域（亦称底板）。跨膜蛋白 DCC 受体作为 Netrin-1 的受体，参与 Netrin-1 的吸引力效应。基于接触的机制促进生长锥穿过底板到达对侧，随后生长锥对中线排斥剂 Slit 的敏感性增强，并远离中线生长。Netrin-1 直接结合至 DCC 的第五个纤连蛋白III结构域，通过 DCC P3 结构域之间的相互作用引发 DCC 聚集，此过程对于产生吸引力响应是必需的。