Cenicriviroc reduces liver fibrosis by restoring the immune cell landscape via inactivating STAT1/NF&B/ERK signaling pathways [prevention_RNA-seq]
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE218497
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资源简介：
This study depicts a novel mechanism by which CVC alleviates liver fibrosis by restoring the immune cell landscape. CVC can inhibit profibrotic gene transcription via inactivating the CCR2-STAT1/NF&B/ERK signaling pathways. One liver fibrosis model was induced by intraperitoneal injection of carbon tetrachloride (CCl4) with wild type for 6 weeks. For the prevention experiment, the wild-type mice were i.p. administered 4 doses of CVC and 2 doses of CCl4 per week for a total of 6 weeks. Control mice received the same volume of olive oil.
创建时间：
2023-08-31
