Age-related changes in gene expression in mouse cochlea

Age-related hearing loss is a multifactorial and progressive process, which negatively impacts quality of life in many senior adults as the number one chronic neurodegenerative condition. This study was done to examine gene expression changes occurring in mouse auditory nerve and cochlear lateral wall tissues that may contribute to age-related hearing loss. In addition to conducting general differential expression analysis, a focused analysis of genes linked to neural cells was done. Young adult (1-3 months) and aged (1.5 year) CBA/CaJ mice were used in the study. Cochlea (2) were used to prepare individual experimental replicates, with three samples for young adults and for aged conditions (n=3).