Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates aPD-L1 therapy
收藏NIAID Data Ecosystem2026-03-14 收录
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The use of probiotics by cancer patients is increasing, including amongst those undergoing immune checkpoint inhibitor therapy. Here, we elucidate a critical microbial host crosstalk between probiotic released aryl hydrocarbon receptor agonist indole 3 aldehyde and CD8 T cells within the tumor microenvironment that potently enhances spontaneous antitumor immunity and facilitates ICI therapy in preclinical melanoma.
创建时间：
2023-01-19
