Data from: SNP genotyping identifies new signatures of selection in a deep sample of West African P. falciparum malaria parasites
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https://datadryad.org/dataset/doi:10.5061/dryad.731f5
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资源简介:
We used a high density SNP array to genotype 75 P. falciparum isolates
recently collected from Senegal and The Gambia in order to search for
signals of selection in this malaria endemic region. We found little
geographic or temporal stratification of the genetic diversity among the
sampled parasites. Through application of the iHS and REHH haplotype-based
tests for positive selection, we found evidence of recent selective sweeps
at a known drug resistance locus, at several known antigenic loci, and at
several genomic regions not previously identified as sites of recent
selection. We discuss the value of deep population-specific genomic
analyses for identifying selection signals within sampled endemic
populations of parasites, which may correspond to local selection
pressures such as distinctive therapeutic regimes or mosquito vectors.
提供机构:
Dryad
创建时间:
2012-06-12



