Enantioselective Friedel–Crafts Alkylation Reactions of 3‑Substituted Indoles with Electron-Deficient Alkenes
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Highly enantioselective Friedel–Crafts C2-alkylation reactions of 3-substituted indoles with α,β-unsaturated esters and nitroalkenes were developed using chiral Lewis acids as catalysts, which afforded chiral indole derivatives bearing C2-benzylic stereogenic centers in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee).
创建时间：
2016-03-28
