Gene Set Enrichment Analysis Predicts Pathways Involved in Inflammation, Cancer, and Hypoxia Are Important for Golden Retrievers with Hemangiosarcoma1.

1The filtered gene list from Golden Retrievers with hemangiosarcoma vs. non-Golden Retrievers with hemangiosarcoma were compared using the GSEA software. ES (Enrichment Score) is a value that represents how well the gene set is enriched within the selected gene list. NES (normalized enrichment score) corrects the ES for differences in gene set size and can be used to compare across gene sets. A high ES or NES indicates that gene set is highly enriched within our gene list. FDR represents the probability that the NES for a gene set gives a false positive finding. The highest FDR shown here is 0.005 indicating that there is a 0.005% chance that the gene set indicates a false positive finding. The lists shown are those gene sets with an NES higher than 2.10.