Characteristics of CML patients at diagnosis in chronic phase.

1CHR: complete hematologic response (normalization of peripheral blood count and no palpable spleen); CCgR: complete cytogenetic response (Ph+ none); PCgR: partial cytogenetic response (Ph+ 1–35%); no CgR: no cytogenetical response (Ph+>95%); <:less than; + 36%–66%) and minimal (Ph+66–90%); CMoR: complete molecular response (transcript non-detectable); MMoR: major molecular response (<0.1%). All these definitions of the clinical response have been assigned according to the European LeukemiaNet. (Numbers in bold: non responder patients, i.e. no CHR, no CgR at 3 and 6 mo; these patients underwent imatinib 800 mg/daily after 6 mo and nilotinib or dasatinib after 12 mo).