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Highly Efficient Synthesis of the Tricyclic Core of Taxol by Cascade Metathesis

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NIAID Data Ecosystem2026-03-08 收录
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An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

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2014-06-20
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