The transcriptional effects of osteocyte-derived mitochondria on endothelial cells

In this study, osteocytes were proved to be capable of delivering mitochondria to endothelial cells in cortical bone and promotes its angiogenesis. By utilizing RNA seq, we investigated the effect of osteocytes-derived mitochondria on endothelial cells. Overall design: bEnd.3 cells were co-cultured with or without mitochondria isolated from MLO-Y4 cells in vitro. After 24 hours, bEnd.3 cells were collected for further RNA-Seq analysis.