Assessing the role of TPL2 in TauP301S mice

ScRNAseq analysis shows •TPL2 KD (kinase dead) reduced TauP301S dependent IEG and MHCII activation states in microglia •TPL2 KD reduced peripheral immune cell infiltration in TauP301S mouse brain Single cell suspensions of mouse hippocampi were obtained by FACS from ~ 9-month-old TPL2 KD mice crossed with TauP301S mice and littermate control mice. Samples analyzed: 1. Tpl2 wt/wt, Tau P301S -/-, n = 3 2. Tpl2 kd/kd, Tau P301S -/-, n = 3 3. Tpl2 wt/wt, Tau P301S +/-, n = 6 4. Tpl2 kd/kd Tau P301S +/-, n = 6