HAMLET, a human milk protein-lipid complex, modulates amoxicillin-induced changes in an ex vivo biofilm model of the oral microbiome

Challenges from infections caused by biofilms and antimicrobial resistance highlight the need for novel antimicrobials that work synergistically with antibiotics and minimize resistance risk. In this study, authors investigated the potential synergistic effect of HAMLET (human alpha-lactalbumin made lethal to tumor cells), found in human milk protein-lipid complex, and amoxicillin on the microbial ecology of an ex-vivo human model of oral biofilm model using a whole metagenomics approach.