Modulation of Long Non–Coding RNAs in Triple-Negative Human Breast Cancer Cells by Tocotrienol–rich Fraction from Palm Oil

This thesis explored how palm oil's tocotrienol-rich fraction (TRF) kills aggressive triple-negative breast cancer (TNBC) cells. It identified long non-coding RNAs (lncRNAs) as important players that help control other genes and enable TRF to kill TNBC cells through multiple pathways, simultaneously. By working through these different mechanisms, TRF can overcome drug resistance - making it a particularly promising future treatment option for this difficult-to-treat cancer.