Expression data of kidneys from Wild-type (WT) or Mincle-deficient (KO) mouse subjected to renal ischemia-reperfusion injury.

Mincle (Macrophage inducible C-type lectin) is a pattern recognition receptor expressed in innate immune cells and can sense cell death, suggesting a role in sterile inflammation. We induced renal ischemia–reperfusion injury to KO and WT mice and collected the kidneys to compare the gene expression. Microarray analysis revealed that the overlap between the genes upregulated in injured kidney vs. sham kidney in WT mice and the genes downregulated in injured kidney in KO mice vs. WT mice included inflammation-related pathways on day 3. We induced renal ischemia–reperfusion injury and collected kidneys at day 1 and day 3 for RNA extraction and hybridization on Affymetrix microarrays.