Multivariable adjusted odds ratios (OR) of colorectal and colon cancer by median of plasma analyte level, HPFS and NHS combined.

*Low: below median level; high: equal or above median level.Median vitamin D levels (controls): HPFS: 29.6 ng/mL; NHS: laboratory batch 1: 23.8 ng/mL; laboratory batch 2: 29.7 ng/mL, laboratory batch 3: 25.5 ng/mL.$Multivariable adjusted for matching factors (age, year and month of blood donation), body mass index (kg/m2, continuous), packyears of smoking (continuous), physical activity (MET-hr week, continuous), intake of alcohol, methionine, folate, retinol, red and processed meat, calcium (all intake covariates as continuous variables), family historyof colorectal cancer (yes vs. no), sex, fasting status (0–2, 3–4, 5–8, ≥9 hours since last meal), aspirin use (†Models for C-Peptide only included participants without self-reported diabetes mellitus.