Structure of BACE Bound to SCH589432
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Structure of BACE Bound to SCH589432 Descriptor: Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE Authors: Strickland, C, Zhu, Z. Deposit date: 2009-12-21 Release date: 2010-02-16 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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2009-12-21
