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Chronologic age and morbidities could converge on gene-specific traits through length-dependent failure of transcript polymerization

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We provide evidence for the decrease of long transcripts during aging using a unique reference transcriptomic survey of 17 mouse organs sampled at 5 timepoints over the lifespan. Transcriptomic profiles of 17 mouse organs, sampled at 4, 9, 12, 18, 24 months of age, were generated by standard illumina RNA-Seq protocols.

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