Supplementary Material for: Gluten-Associated Neurological Disorders: A Cases Series

Gluten-associated disorders, including celiac disease (CeD) and non-celiac gluten sensitivity (NCGS), can present with various extra-intestinal neurologic manifestations, including sensory neuropathy, ataxia, headaches, and seizures. For many patients with neurological presentations who initially lack gastrointestinal (GI) symptoms, diagnosis remains challenging. Once diagnosed, while a gluten-free diet (GFD) has been the mainstay of treating gluten-associated neurological disorders (GAND) for many years, this approach may only prevent progression of disease without reversal of symptoms. In this case series, we present three interesting patients with GAND across a spectrum of gluten-associated disorders (GAD) severity, from gluten sensitivity, to CeD, to refractory CeD, illustrating variable presentations and treatment approaches for this underdiagnosed population.