Single_cell_transcriptomics_in_olfactory_sensory_neurons

The olfactory gene repertoire is largely species-specific, shaped by the nature and necessity of chemosensory information for survival in each species' niche. Current scientific opinion holds the mouse olfactory receptor neuron (OSN) repertoire is comprised of approximately 1200 different classes of neurons, and that each class is molecularly defined by the abundant expression of a single olfactory receptor, with the other receptors being silenced in that cell. By investigating the transcriptomes of single olfactory sensory neurons from mouse we can determine whether the canonical one cell - one receptor hypothesis holds true.