DYNLL1

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

细胞质动力蛋白是一种由约1,200 kD组成的巨型酶复合物。该复合物包含两个由动力蛋白重链主要形成的力生成头部，以及连接头部至基底域的茎部，基底域包含不同数量的辅助中间链。该复合物参与细胞内运输和运动。本记录中描述的蛋白为轻链，作为该复合物的一部分存在，但同时也与神经元一氧化氮合酶发生物理相互作用并抑制其活性。该蛋白的结合会导致神经元一氧化氮合酶二聚体的不稳定，而这一构象对于活性是必要的，它可能通过影响一氧化氮合酶的活性来调节多种生物学过程。已鉴定出不同的转录剪接变异体。[提供者：RefSeq，2008年7月]