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Inflammatory Cytokines shape a Changing DNA Methylome in Monocytes Mirroring Disease Activity in Rheumatoid Arthritis (in vitro)

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NIAID Data Ecosystem2026-03-14 收录
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Genome wide DNA methylation profiling of CD11b+CD33+ cells after treatment with different cytokines. The Illumina Infinium MethylationEPIC Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpGs in CD11b+CD33+ cells isolated from PBMCs treated in vitro for 4 days with TNF-alpha, IFN-alpha, IFN-gamma or control. Bisulphite converted DNA from the 12 samples were hybridised to the Illumina Infinium MethylationEPIC Beadchip.

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2022-12-15
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