Cryo-EM structure of Shigella flexneri LptDE bound by a Bicyclic peptide molecule (Compound 1)

Cryo-EM structure of Shigella flexneri LptDE bound by a Bicyclic peptide molecule (Compound 1) Descriptor: 1-[4,7-bis(2-chloranylethanoyl)-1,4,7-triazonan-1-yl]-2-chloranyl-ethanone, Compound 1 - Bicyclic Peptide binder, DODECYL-BETA-D-MALTOSIDE, ... Authors: Allyjaun, S, Newman, H, Dunbar, E, Hardwick, S.W, Chirgadze, D.Y, van den Berg, B, Hubbard, J. Deposit date: 2025-02-06 Release date: 2025-10-15 Last modified: 2025-11-05 Method: ELECTRON MICROSCOPY (2.41 Å) Cite: High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM. J.Med.Chem., 68, 2025