CN133 hampers tumor growth in patient-derived pediatric ependymoma models

HDACs are known to play crucial roles in cancer by deacetylating histones and non-histone substrates, leading to altered expression of genes involved in several cellular processes such as cell cycle control, apoptosis, DNA-damage response, angiogenesis, and autophagy, among othersto caracterize the transcriptomic changes induced by CN133 treatment on EPN cells, a microarray expression analysis of the EPP cell line treated with CN133 was performed Epp cell lines were treated for 5h with vehicle or CN133 at 1uM concentration. 3 samples were performed for each condictions