File S1 - Pleiotropic Effect of Common Variants at ABO Glycosyltranferase Locus in 9q32 on Plasma Levels of Pancreatic Lipase and Angiotensin Converting Enzyme

Supporting Information. Figure S1, Polar transformed cluster plot for the significant SNPs surviving the two-stage study for the Takahata and Yamagata. Figure S2, Polar transformed cluster plot for the significant SNPs surviving the two-stage study for the Takahata and Yamagata. Figure S3, Association patterns for SNPs in the 186 kb region from 136,040,829 to 136,227,260 of 9q32 with other clinical test values in the Takahata population, whose range is identical to that in Fig. 2a. The ABO locus is located within about 30 kb on the center of this range of 186 kb (Fig. 2a), which is enough to cover the ABO locus. Figure S4, The regression diagnosis plots for ACE and P-LIP after Box-Cox transformations or untransformations. Methods S1. Table S1, Associations of imputed genotypes in the ABO locus with P-LIP in Takahata population. Table S2, Associations of imputed genotypes in the ABO locus with ACE in Takahata population. Table S3, Associations of ABO gene in 9q32 with P-LIP or ACE levels after adjustment by smoking or Box-Cox transformation of trait values. Table S4, Associations of ACE1 in 17q23.3 with ACE level after adjustment by smoking or Box-Cox transformation of trait values. Table S5, Associations of ABO gene in 9q32 with P-LIP or ACE levels after adjustment or subgroup by treatment. Table S6, Associations of ACE1 gene in 17q23.2 with ACE level after adjustment or subgroup by treatment. Table S7, SNPs associated with P-LIP and/or ACE levels at a genome-wide significance level. Table S8, Associations of ABO gene in 9q32 with P-LIP and ACE in combined population. Table S9, Associations of ACE gene in 17q23.2 with ACE in combined population. Table S10, Sample numbers removed by each quality control filter. Text S1, Organization and all contributors list of Yamagata University Genomic Cohort Consortium.
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