Data about a rat embryonic stem cell model at pre- and post-implantation stage to reduce in vivo developmental toxicity testing

The present dataset file contains data about the characterization of an in vitro model based on a line of Rat Embryonic Stem Cells (RESCs) line. The RESCs culture is easy to use and suitable for wide-scale screening, mimicking two different developmental stages: i) pre-implant model, as undifferentiated pluripotent cells, and ii) post-implant model, driving cell differentiation toward the neuroectodermal lineage. The in vitro platform model was validated by using 2,2',6,6'-tetrabromobisphenol A (TBBPA) as test compound, a toxic flame retardant which acts as an endocrine disruptor chemical, targeting the thyroid hormone (TH) signal. The in vitro platform was validated by using 2,2',6,6'-tetrabromobisphenol A (TBBPA) as test compound, a toxic flame retardant which acts as an endocrine disruptor chemical, targeting the thyroid hormone (TH) signal. The dataset contains all the characterization data, the PCRarray full expression data and functional experiments.