Summary of Compass and GeneMANIA performance on the phenotype-based benchmarks.

Predictive performance of Compass and GeneMANIA, as measured by the area under the receiver operating characteristic (ROC) curve (AUC), mean average precision (Pmean) and precision at recall 0.1 (Pr = 0.1), on the phenotype-based benchmarks. The RNAi benchmark consists of 45 gene sets (27 for human and 18 for fly). Standard deviations (sd) are reported in parenthesis. The ageing benchmark consists of 17 genes associated with a long lived phenotype in a knock-out screen. For the RNAi benchmark, p-values are derived from a two-tailed Wilcoxon ranked sum test. For the ageing benchmark (which consists of only one gene set), the statistical significance of the difference in performance was evaluated by comparing how highly each long lived mutant was ranked by Compass and Genemania, giving a p-value of 0.0168 (two-tailed Wilcoxon sing-rank test).
Summary of Compass and GeneMANIA performance on the phenotype-based benchmarks.