Methods for engineering highly active T cell for immunotherapy
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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The present invention relates to methods for developing engineered T-cells for immunotherapy and more specifically to methods for modifying T-cells by inactivating at immune checkpoint genes， preferably at least two selected from different pathways， to increase T-cell immune activity. This method involves the use of specific rare cutting endonucleases， in particular TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides， to precisely target a selection of key genes in T-cells， which are available from donors or from culture of primary cells. The invention opens the way to highly efficient adoptive immunotherapy strategies for treating cancer and viral infections.
提供机构：
国家林业和草原科学数据中心
创建时间：
2023-02-12
