Comparative genome analysis of Erysipelothrix rhusiopathiae isolated from domestic pigs and wild boars reveals host adaptation and selective pressure from the use of antibiotics

The disease erysipelas caused by Erysipelothrix rhusiopathiae (ER) is a major concern in pig production, with certain serovars considered to cause most of the severe outbreaks. In the present study the genomes of ER from pigs and wild boars (n=158) were compared in terms of whole-genome SNP variation, accessory genome content, and the presence of genetic antibiotic resistance determinants. The aim was to investigate if genetic features among ER were associated with isolate origin in order to better estimate the risk of transmission of porcine-adapted strains from wild boars to free-range pigs and to increase our understanding of the evolution of ER.