Pulmonary epithelial and endothelial cell damage, loss of repair, inhibition of fibrinolysis and cellular senscence in fatal COVID-19

Key pulmonary findings included: 1) Loss or damage to respiratory epithelial basal cells, alveolar epithelial cells, 2) Impaired clot fibrinolysis with increased levels of plasma and lung PAI-1, and 3) modulation of cellular senescence markers. Inregration of lung gene expression and viral load, pathology and plasma protein from autopsy tissue from COVID-19 patients was compared normal lung tissue