Inhibition of proliferation of malaria parasites and of human foreskin fibroblasts by Compounds 1, 10, 12, and 13 and control compounds.

Dose response curves were performed for Compound 1 and three of its analogs to quantify inhibition of proliferation of P. falciparum strains 3D7 (not drug resistant) and K1 (multi-drug resistant) and human foreskin fibroblasts (BJ cells). The numbers under each cell line refer to the EC50 values in μM units. Columns marked 95% Cl refer to the 95% confidence limits for determination of EC50 values. Control experiments were also performed with the anti-malarial compounds mefloquine and chloroquine and with gambogic acid, which inhibits proliferation of mammalian cells. ND indicates not done.
Inhibition of proliferation of malaria parasites and of human foreskin fibroblasts by Compounds 1, 10, 12, and 13 and control compounds.