Copper-Mediated Oxidative Coupling of Benzamides with Maleimides via Directed C–H Cleavage
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https://figshare.com/articles/dataset/Copper_Mediated_Oxidative_Coupling_of_Benzamides_with_Maleimides_via_Directed_C_H_Cleavage/2139061
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资源简介:
A Cu(OAc)2/Cy2NMe-mediated oxidative direct coupling of benzamides
with maleimides has been developed. The aromatic C–H alkenylation
with the aid of an 8-aminoquinoline-based bidentate directing group
is followed by an intramolecular aza-Michael-type addition to form
the isoindolone-incorporated spirosuccinimides, which are of potent
interest in medicinal chemistry.
创建时间:
2016-02-13



