NF-κB binding sites within housekeeping gene promoters.

2000 bp of 5' and 500 bp of 3' flanking sequences were searched for NF-κB binding sites (GGGRNNYYCC; whereby R is a purine and Y is a pyrimidine) and compared to the average binding site distribution of similarly-sized random genomic or promoter sequences. z-statistics show that B2M and GAPDH promoters contain significantly more NF-κB binding sites than the other housekeeping genes or the average genomic or promoter sequence, whereas NF-κB binding sites are underrepresented in PSMB6 and HPRT1.