Landscape of White Adipose Tissue Diurnal Rhythms during Time-restricted Feeding: Phosphorylation

Meal timing is essential in synchronization of circadian rhythms in different organ systems through clock-dependent and -independent mechanisms. Adipose tissue is a critical metabolic and endocrine organ whose circadian clock and transcriptome can be reset by meal timing. However, it remains largely unexplored how circadian rhythms in adipose tissue are organized in time-restricted feeding that intervenes meal timing. Here, we applied quantitative phospho-proteomics to characterize circadian features associated with ad libitum feeding (ALF), day/inactive phase-restricted feeding (DRF) and night/active phase-restricted feeding (NRF) in female mice.