DRD5 signaling in B cells

Neuronal signals have emerged as pivotal regulators of B cells that regulate antitumor immunity and tumor progression. The functional relevance and mechanistic basis of effects of the neurotransmitter dopamine (DA) on tumor immunity remain unclear. Here, we found that the abundance of DA was positively correlated with circulating B cell numbers and potently activated B cell responses in a DRD5-receptor-dependent manner. We found that B cells from drd5fl/flcd19-cre mice have no significant different from B cells fromdrd5fl/fl mice.