The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6
收藏Protein Data Bank Japan2025-06-18 更新2026-04-19 收录
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The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6 Descriptor: (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... Authors: Xie, X, Mao, H, Liau, B, Zheng, N. Deposit date: 2024-01-15 Release date: 2024-12-04 Last modified: 2025-06-18 Method: ELECTRON MICROSCOPY (3.77 Å) Cite: UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Nature, 639, 2025
创建时间：
2024-01-15
