IUPHAR/BPS Guide to PHARMACOLOGY

The information in the database is presented at two levels: the initial view or landing pages for each target family provide expert-curated overviews of the key properties and selective ligands and tool compounds available. For selected targets more detailed introductory chapters for each family are available along with curated information on the pharmacological, physiological, structural, genetic and pathophysiogical properties of each target. Recent extensions to the database provide specific portals for accessing data on immunopharmacology (IUPHAR Guide to IMMUNOPHARMACOLOGY; www.guidetoimmunopharmacology.org), and on malaria pharmacology (IUPHAR/MMV Guide to MALARIA PHARMACOLOGY; www.guidetomalariapharmacology.org). The database is enhanced with hyperlinks to additional information in other databases including Ensembl, UniProt, PubChem and ChEMBL, as well as curated chemical information and literature citations in PubMed.该数据库的信息分为两个层级呈现：各靶点家族的初始浏览页或着陆页将提供经专家精选整理的关键特性、现有选择性配体及工具化合物的概述。针对部分选定靶点，各家族还可获取更详尽的介绍章节，同时附带经整理的各靶点药理学、生理学、结构学、遗传学及病理生理学特性相关信息。该数据库近期新增了两个专属门户，分别用于访问免疫药理学数据（国际药理学联合会（International Union of Basic and Clinical Pharmacology，IUPHAR）免疫药理学指南；www.guidetoimmunopharmacology.org）以及疟疾药理学数据（IUPHAR/MMV 疟疾药理学指南；www.guidetomalariapharmacology.org）。数据库还增设了指向其他数据库额外信息的超链接，涵盖Ensembl、UniProt、PubChem及ChEMBL，同时附带经整理的化学信息及PubMed中的文献引用。

搜集汇总

背景与挑战

背景概述

IUPHAR/BPS药理学指南是一个专家整理的数据库，提供药物靶点家族概览、详细药理特性及选择性配体信息。该数据库扩展了免疫药理学和疟疾药理学子门户，并链接至外部数据库如UniProt和PubMed以增强数据访问。