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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP778902

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Protein Data Bank Japan2025-12-03 更新2026-08-24 收录
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP778902 Descriptor: FE (III) ION, Telotristat, Tryptophan 5-hydroxylase 1 Authors: Schuetz, A, Heinemann, U. Deposit date: 2024-11-13 Release date: 2025-07-16 Last modified: 2025-12-03 Method: X-RAY DIFFRACTION (2.58925907124 Å) Cite: Selectivity and Safety Characterization of a Xanthine-Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis. Acs Pharmacol Transl Sci, 8, 2025

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2024-11-13
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