Supplementary Material for: Lymph Node Ratio Can Better Predict Prognosis than Absolute Number of Positive Lymph Nodes in Operable Cervical Carcinoma

<b><i>Background:</i></b> Nodal status is the most important prognostic factor in cervical cancer. However, further risk stratification in node positive cervical cancer patients is warranted for optimal therapeutic decisions. <b><i>Material and Methods:</i></b> Nodal positive patients (<i>n</i> = 86) were retrospectively stratified into two groups according to either number of positive nodes (&gt;3 vs. 1–3) or lymph node ratio (LNR) (≥10 vs. &lt;10% and &gt;6.6 vs. ≤6.6%). Univariable log-rank tests and both univariable and adjusted multivariable Cox regression models were used to evaluate the association between number of positive nodes or LNR and disease-free survival (DFS) and overall survival (OS). <b><i>Results:</i></b> LNR was significantly associated with worse DFS in adjusted multivariable analysis, both when categorized as ≥10 versus &lt;10% (HR 2.25, 95% CI 1.06–4.76, <i>p</i> = 0.034) and when categorized as &gt;6.6 versus ≤6.6% (HR 2.79, 95% CI 1.23–6.37, <i>p</i> = 0.015). However, we found no significant association between number of positive nodes or LNR and OS. <b><i>Discussion:</i></b>In operable node-positive cervical cancer, both number of positive lymph nodes and LNR can be used for further risk stratification with regard to DFS but not OS.