Single-cell transcriptome analysis reveals distinct cell populations in dorsal root ganglia and their potential roles in diabetic peripheral neuropathy

Diabetic peripheral neuropathy (DPN) is the most common form of neuropathy, and have considerable morbidity, which occurs in approximately 50% of diabetic patients. Here, we performed scRNA-seq technology using 10× Genomics sequencing on DRG tissues isolated from control and DPN rats, to identify the cell type composition of DRG, and to reveal the roles of different cell types in mediating DPN.糖尿病周围神经病变（DPN）是最为常见的神经病变类型，发病率较高，约50%的糖尿病患者会罹患此类病变。本研究借助10× Genomics测序平台开展单细胞RNA测序（single-cell RNA sequencing, scRNA-seq），对从对照组与DPN模型大鼠体内分离得到的背根神经节（dorsal root ganglion, DRG）组织进行检测，旨在明确DRG的细胞类型组成，并揭示不同细胞类型在介导DPN发生发展中的作用。