List of leading positions located in the 7-TMs of the β₂-AR and rhodopsin (Rho) that are in contact with the co-crystallized ligand (underlined) and/or qualified as leading positions (in bold and marked with an <b>*</b>).

The MI data refer to the analysis performed on the MSA of the 7-TMs class A receptors using Dunn, Wahl and Gloor's (2008) method [37] to obtain MIp the corrected MI. The position has highest MI (among all other inter-TM positions) with the listed pair position (pp). Rank is the MI ranking of that pair using the class A 7-TM MSA (287 sequences) and the degree is calculated using MIp graph from top 600 MIp pairs. Positions are not included in the MIp graph have “n.a.” ascribed to the degree value. Entropy and MI are measured in bits.