Emergence and Increased Epidemic Potential of Dengue Variants with the NS5V357E Mutation after Consecutive Years of Transmission

We discover the molecular events involved in overwintering and increased disease severity between consecutive dengue virus serotype 2 outbreaks from 2001 to 2003 in Taiwan. The virus evolved from the early-epidemic strain (Ia) to the late-epidemic strains (Ib and II), featuring three amino acid differences. The data for plaque and foci morphology in Figures 1 and 2, is provided.

本研究揭示了2001至2003年间台湾地区连续发生的登革热病毒血清型2暴发中，越冬期间以及疾病严重程度加剧所涉及的分子事件。病毒从早期流行株（Ia）进化至后期流行株（Ib及II），表现出三个氨基酸差异。图1和图2中提供的斑点板和焦点形态数据得以呈现。