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Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692

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Protein Data Bank Japan2024-11-20 更新2026-03-21 收录
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Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692 Descriptor: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence Authors: Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. Deposit date: 2020-06-26 Release date: 2021-02-10 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.639 Å) Cite: Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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2020-06-26
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