Concise Assembly of the Polycyclic Frameworks Associated with the Hapalindole and Fischerindole Alkaloids
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https://figshare.com/articles/dataset/Concise_Assembly_of_the_Polycyclic_Frameworks_Associated_with_the_Hapalindole_and_Fischerindole_Alkaloids/3054223
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资源简介：
Reaction of N-methylindole (4) with 6,6-dibromobicyclo[3.1.0]hexane (5) in the presence of silver tetrafluoroborate affords conjugate 7 in 67%
yield. This product can be readily elaborated to compounds 12b and 13b which embody the polycyclic frameworks associated with members
of the hapalindole and fischerindole classes of alkaloids. The chiral-auxiliary-substituted 6,6-dibromobicyclo[3.1.0]hexanes 21 and 22 react
with indole to give adducts likely to be useful in the enantioselective total synthesis of the title alkaloids.
创建时间：
2016-02-29
