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Targeting epigenetic networks mediated by Prmt1 and Kdm4c in acute myeloid leukemia
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2019-05-14
相关数据集
Table 5_Local Promoter Methylation Disorder algorithm reveals bidirectional epigenetic disruption in DNMT3A-mutated AML and predicts azacitidine treatment response.xlsx
BackgroundDNMT3A mutations occur in 20-25% of acute myeloid leukemia (AML) cases and are associated with poor prognosis, yet the epigenetic mechanisms underlying treatment response remain poorly under
NIAID Data Ecosystem80
Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]. Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]
To determine whether changes in histone modifications directly correlate with changes in transcription, THP1 AML cells were treated with a potent and selective LSD1 inhibitor (OG86, 250nM) and then su
NIAID Data Ecosystem50
Interplay between CoREST, p300 and retinoic acid signaling in Acute myeloid leukemia [RNA-seq]
The histone demethylase KDM1A (LSD1), a component of the CoREST corepressor complex, is highly expressed in hematologic malignancies and regulates hematopoietic differentiation. Despite its essential
NIAID Data Ecosystem20
ATAC-seq time course in mouse acute myeloid leukemia cells upon PU.1 restoration and knockdown
We have utilized advanced RNAi technology to dynamically restore and subsequently knock down endogenous PU.1 expression in p53-deficient AML cells, which respectively causes differentiation and de-dif
NIAID Data Ecosystem50
PRMT5 methylome profiling uncovers a direct link to splicing regulation in human acute myeloid leukemia
Protein arginine methyltransferase 5 (PRMT5) belongs to the class II arginine methyltransferases and catalyzes monomethylation and symmetrical dimethylation of arginines on proteins. It has recently e
NIAID Data Ecosystem20
